{"created":"2024-07-21T11:06:38.419049+00:00","id":2000098,"links":{},"metadata":{"_buckets":{"deposit":"82e82784-e9ef-40aa-a20b-8082e7550e96"},"_deposit":{"created_by":11,"id":"2000098","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000098"},"status":"published"},"_oai":{"id":"oai:usp.repo.nii.ac.jp:02000098","sets":["1719210320356:1719211028262:1719468445589"]},"author_link":[],"item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhancement effects of antimicrobial activities of β-lactam antibiotics by combination with persimmon tannin against β-lactamase-producing Staphylococcus aureus","subitem_title_language":"en"}]},"item_1617186385884":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"柿由来タンニンによるβ-ラクタマーゼ産生黄色ブドウ球菌に対するペニシリン系抗生物質の抗菌活性増強効果","subitem_alternative_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Horie, Hitoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Hiroyasu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Taya, Kahoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hamada, Setsuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fujii, Yuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nozawa, Koohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwama, Masanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwama, Masanori","creatorNameLang":"en"}]}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"β-lactamase-producing Staphylococcus aureus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"persimmon tannin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diospyros kaki","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antimicrobial activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"blaZ gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-ラクタマーゼ産生黄色ブドウ球菌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"柿由来タンニン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"抗菌活性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"blaZ遺伝子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Background　β-lactamase-producing Staphylococcus　aureus is one of the most important bacterial pathogens. Combinations of β-lactam antibiotics with β-lactamase inhibitors such as sulbactam and tazobactam are useful therapeutic methods for combating infections of β-lactamase-producing bacteria. However, bacterial strains which have acquired inhibitor resistance have appeared so new therapeutic agents or new approaches are urgently needed for β-lactamase-producing bacteria. Objective　We investigated the antibacterial activity of persimmon tannin derived from the Diospyros kaki cultivar \"mishirazu\" against β-lactamase-producing S. aureus strains, and the enhancement effects of the antimicrobial activity of β-lactam antibiotics against those strains by combining them with persimmon tannin. The possibility of this combination as a new therapeutic agent against β-lactamase-producing bacteria was examined. Methods　The enhancement effects of the antimicrobial activities of β-lactam antibiotics in combination with persimmon tannin were tested by using an MBC (minimum bactericidal concentration) assay. Results　The antimicrobial activities of β-lactam antibiotics against β-lactamase-producing S. aureus strains were obviously enhanced by the combination with persimmon tannin. Furthermore, it was clarified that the enhancement effect by persimmon tannin was due to the decomposition control of β-lactam antibiotics by β-lactamase. Conclusion　The combined persimmon tannin/β-lactam antibiotic is expected to be a new therapeutic method and/or a new therapeutic agent against infectious diseases caused by microorganisms producing β-lactamase.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"背景　β‐ラクタマーゼ産生黄色ブドウ球菌は、多くのβ‐ラクタム系抗生物質に対して耐性である。更にこの細菌においては、スルバクタムやタゾバクタムのようなβ‐ ラクタマーゼインヒビターと、β‐ラクタム系抗生物質を組み合わせて用いても、効果を示さないインヒピター耐性菌も出現している。β‐ラクタマーゼ産生細菌による感染症に対し、新しい治療薬や治療方法の開発が急務となっている。 目的　柿由来タンニンが、β‐ラクタマーゼ産生細菌に対する新しい医薬品となる可能性について検討を行うため、同タンニンのβ‐ラクタマーゼ産生黄色ブドウ球菌に対する抗菌活性、並びに同タンニンの同細菌に対する、β‐ラクタム系抗生物質の抗菌活性を増強する効果について解析を行った。 方法　柿由来タンニンの抗菌活性およびβ‐ラクタム系抗生物質の抗菌活性増強効果は、MIC （minimuminhibitory concentration) 法を基にしたMBC（minimum bactericidal concentration) 法で試験した。また、柿由来タンニンのβ‐ラクタマーゼに対する活性阻害効果に関しても、同様にMBC法で試験した。 結果　β‐ラクタマーゼ産生黄色ブドウ球菌に対してほとんど抗菌活性を示さなかったβ‐ラクタム系抗生物質が、柿由来タンニンと併用することで顕著な抗菌活性を示した。この効果は、同タンニンによるβ‐ラクタマーゼの活性阻害効果によるものであることが、強く示唆された。 結論　柿由来タンニンは、単独あるいはβ‐ラクタム系抗生物質と組み合わせて用いることにより、β‐ラクタマーゼ産生黄色ブドウ球菌による感染症に対して、高い安全性と有効性をもった新しい医薬品や治療方法の開発に結びつく可能性が期待される。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"滋賀県立大学人間看護学部","subitem_publisher_language":"ja"}]},"item_1617186702042":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"16","bibliographicPageStart":"9","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"人間看護学研究","bibliographic_titleLang":"ja"}]}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617604990215":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available"}],"filename":"JHNS 008 009.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://usp.repo.nii.ac.jp/record/2000098/files/JHNS 008 009.pdf"},"version_id":"2891f9dc-fb25-4a4e-a795-9161644549d8"}]},"item_1623818042585":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24795/nk008_009-016","subitem_identifier_reg_type":"JaLC"}]},"item_1719197134224":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13492721","subitem_source_identifier_type":"PISSN"}]},"item_1719375414771":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1720772569415":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11960281","subitem_source_identifier_type":"NCID"}]},"item_1724975283598":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_title":"Enhancement effects of antimicrobial activities of β-lactam antibiotics by combination with persimmon tannin against β-lactamase-producing Staphylococcus aureus","item_type_id":"40001","owner":"11","path":["1719468445589"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-11-27"},"publish_date":"2013-11-27","publish_status":"0","recid":"2000098","relation_version_is_last":true,"title":["Enhancement effects of antimicrobial activities of β-lactam antibiotics by combination with persimmon tannin against β-lactamase-producing Staphylococcus aureus"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-09-06T06:13:59.630433+00:00"}